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Hypericum Perforatum Extract

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Additional Information

  • Product Type:
    Raw Material/Extract
  • Active Ingredients:
    hypericin
  • Marketed Country:
    America,India,Mexico
  • Targeted Country:
    America,India,Mexico
  • Recommended Storage Condition:
    Keep in Cool and Dry Place
  • Shelf Life Period:
    24 Months
  • Health Function:
    Immunity Booster, Stress relief, Stress & Mood
  • Supply ability:
    20000 Kilogram Months
  • Lead Time:
    7-10 Days
  • Nearest Port:
    Shanghai
  • Accepted Delivery Terms:
    FOB
  • Accepted Payment Currency:
    USD
  • Accepted Payment Type:
    Paypal, T/T

Details

Hypericum Perforatum Introduction
Hypericum Perforatum is a ellow-flowering, stoloniferousor sarmentose, perennial herb indigenous to Europe, which has been introduced to many temperate areas of the world and grows wild in many meadows. The common name comes from its traditional flowering and harvesting on St John's day, 24 June. The genus name Hypericum is derived from the Greek words hyper and eikon, in reference to the traditional use of the plant to ward off evil, by hanging plants over a religious icon in the house during St John's day. The species name perforatum refers to the presence of small oil glands in the leaves that look like windows, which can be seen when they are held against the light.
 
St John's Wort is a perennial plant with extensive, creeping rhizomes. Its stems are erect, branched in the upper section, and can grow to 1 m high. It has opposing, stalkless, narrow, oblong leaves that are 12 mm long or slightly larger. The leaves are yellow-green in color, with transparent dots throughout the tissue and occasionally with a few black dots on the lower surface.[1] Leaves exhibit obvious translucent dots when held up to the light, giving them a 'perforated' appearance, hence the plant's Latin name.
 
Its flowers measure up to 2.5 cm across, have five petals, and are colored bright yellow with conspicuous black dots. The flowers appear in broad cymes at the ends of the upper branches, between late spring and early to mid summer. The sepals are pointed, with glandular dots in the tissue. There are many stamens, which are united at the base into three bundles. The pollen grains are ellipsoidal.
 
What is Hypericin?
Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as anantibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine 
andepinephrine.
 
It was initially believed that the anti-depressant pharmacological activity of hypericin was due to inhibition of monoamine oxidase enzyme. The crude extract of Hypericum is a weak inhibitor of MAO-A and MAO-B. Isolated hypericin does not display this activity, but does have some affinity for NMDA receptors. This points in the direction that other constituents are responsible for the MAOI effect. The current belief is that the mechanism of antidepressant activity is due to the inhibition of reuptake of certain neurotransmitters.
 
The large chromophore system in the molecule means that it can cause photosensitivity when ingested beyond threshold amounts.  Photosensitivity is often seen in animals that have been allowed to graze on St. John's Wort. Because hypericin accumulates preferentially in cancerous tissues, it is also used as an indicator of cancerous cells. In addition, hypericin is under research as an agent in photodynamic therapy, whereby a biochemical is absorbed by an organism to be later activated with spectrum-specific light from specialized lamps or laser sources, for therapeutic purposes. The antibacterial and antiviral effects of hypericin are also believed to arise from its ability for photo-oxidation of cells and viral particles.
Hypericin derives from polyketides cyclisation.
 
Specification 
Product: Hypericum Perforatum Extract/St. John's Wort P.E
Active Ingredient: Hypericins
Extract Source: Hypericum Perforatum L.
Part of the Plant Used: Flower
Appearance: Brown-black Powder
Test Method: UV

Specification: 0.3% Hypericins 
Extract Method: Ethanol& Water
Usage: Pharmaceuticals, Healthcares, and Cosmetics
CAS NO: 548-04-9
Molecular Formula: C30H16O8
Molecular Weight: 504.45

Functions
1. St John's Wort is widely known as an herbal treatment for depression. In some countries, such as Germany, it is commonly prescribed for mild depression, especially in children and adolescents.[6] It is proposed that the mechanism of action of St. John's wort is due to the inhibition of reuptake of certain neurotransmitters.
2. St. John's Wort is also being studied for anxiety because, in some studies on depression, people taking St. John's wort also reported an improvement in anxiety. More research is needed
3. St. John's Wort has also been suggested as a possible treatment for OCD because the same medications (antidepressants) are often used for OCD, and because of promising results from a preliminary study. A later study on St. John's wort, however, didn’t find it more effective than a placebo for OCD.
4. Oil of St. John's Wort, applied to the skin, was a folk remedy for skin injuries, nerve pain, burns and hemorrhoids. Although the oil is sold in some herbal stores, creams are also available. Some are standardized to hypericin or hyperforin, which are thought to have anti-inflammatory and antibacterial effects. St. John's wort also contains tannins, naturally occurring compounds thought to relieve skin irritations, such as those resulting from minor cuts.
5. Some alternative practitioners recommend St. John's wort for ear pain due to an ear infection (otitis media). In a study of more than 100 children, a combination herbal ear drop that contained St. John's wort, garlic, calendula and mullein was found to be as effective as conventional ear drops.
6. St. John's wort is being explored for smoking cessation. Although promising, well-designed studies are needed.
7. St. John's wort has also been explored for conditions that can have psychological symptoms, such as insomnia, menopausal symptoms, premenstrual syndrome, seasonal affective disorder and attention deficit disorder. Further studies are needed before recommendations can be made.
 
Application

1.Often used as additives, with distinct fragrance smell, it can promote digestion and increase appetite.
2.Added into a large amount of oral cleaning products, such as dentifrices, mouthwash and tooth powder.
3.Because of the function of inhibition and paralysis to sensory nerve endings, it can be used as counter irritant.
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